APA (American Psychiatric Association): Diagnostic and statistical manual of mental disorders, Fifth Edition. Arlington, VA. American Psychiatric Association 2013. dsm.psychiatryonline.org. Accessed 1 Jun 2013.

Hoek HW, van Hoeken D. Review of the prevalence and incidence of eating disorders. Int J Eat Disord. 2003;34:383–96. https://doi.org/10.1002/eat.10222

Article 
PubMed 

Google Scholar 

Qian J, Hu Q, Wan Y, Li T, Wu M, Ren Z, et al. Prevalence of eating disorders in the general population: a systematic review. Shanghai Arch Psychiatry. 2013;25:212–23. https://doi.org/10.3969/j.issn.1002-0829.2013.04.003

Article 
PubMed 
PubMed Central 

Google Scholar 

Kessler RC, Berglund PA, Chiu WT, Deitz AC, Hudson JI, Shahly V, et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013;73:904–14. https://doi.org/10.1016/j.biopsych.2012.11.020

Article 
PubMed 
PubMed Central 

Google Scholar 

Hudson JI, Hiripi E, Pope HG Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry. 2007;61:348–58. https://doi.org/10.1016/j.biopsych.2006.03.040

Article 
PubMed 

Google Scholar 

Fairburn CG, Cooper Z, Doll HA, Norman P, O’Connor M. The natural course of bulimia nervosa and binge eating disorder in young women. Arch Gen Psychiatry. 2000;57:659–65. https://doi.org/10.1001/archpsyc.57.7.659

Article 
CAS 
PubMed 

Google Scholar 

Goldschmidt AB, Le Grange D, Powers P, Crow SJ, Hill LL, Peterson CB, et al. Eating disorder symptomatology in normal-weight vs. obese individuals with binge eating disorder. Obesity. 2011;19:1515–8. https://doi.org/10.1038/oby.2011.24

Article 
PubMed 

Google Scholar 

Micali N, Solmi F, Horton NJ, Crosby RD, Eddy KT, Calzo JP, et al. Adolescent eating disorders predict psychiatric, high-risk behaviors and weight outcomes in young adulthood. J Am Acad Child Adolesc Psychiatry. 2015;54:652–659.e1. https://doi.org/10.1016/j.jaac.2015.05.009

Article 
PubMed 
PubMed Central 

Google Scholar 

Mitchell JE, King WC, Courcoulas A, Dakin G, Elder K, Engel S, et al. Eating behavior and eating disorders in adults before bariatric surgery. Int J Eat Disord. 2015;48:215–22. https://doi.org/10.1002/eat.22275

Article 
PubMed 

Google Scholar 

Sunovion Press Release. Sunovion announces acceptance by the U.S. FDA of the new drug application for dasotraline for thetreatment of adults with moderate-to-severe binge eating disorder—July 2019. https://s23.q4cdn.com/866595044/files/doc_news/Sunovion-Announces-Acceptance-by-the-US-FDA-of-the-New-Drug-Application-for-Dasotraline-for-the-Treatment-of-Adults-with-Moderate-to-31OWJ.pdf.

Sunovion Press Release. Sunovion Discontinues Dasotraline Program – May 2020. https://s23.q4cdn.com/866595044/files/doc_news/Sunovion-Discontinues-Dasotraline-Program-2020.pdf.

APA (American Psychiatric Association): Diagnostic and statistical manual of mental disorders, Fourth Edition – Text Revised. Arlington, VA. American Psychiatric Association. 2000.

McElroy SL, Hudson JI, Mitchell JE, Wilfley D, Ferreira-Cornwell MC, Gao J, et al. Efficacy and safety of lisdexamfetamine for treatment of adults with moderate to severe binge-eating disorder: a randomized clinical trial. JAMA Psychiatry. 2015;72:235–46. https://doi.org/10.1001/jamapsychiatry.2014.2162

Article 
PubMed 

Google Scholar 

McElroy SL, Mitchell JE, Wilfley D, Gasior M, Ferreira-Cornwell MC, McKay M, et al. Lisdexamfetamine dimesylate effects on binge eating behaviour and obsessive-compulsive and impulsive features in adults with binge eating disorder. Eur Eat Disord Rev. 2016;24:223–31. https://doi.org/10.1002/erv.2418

Article 
PubMed 

Google Scholar 

McElroy SL, Hudson J, Ferreira-Cornwell MC, Radewonuk J, Whitaker T, Gasior M. Lisdexamfetamine dimesylate for adults with moderate to severe binge eating disorder: results of two pivotal phase 3 randomized controlled trials. Neuropsychopharmacology. 2016;41:1251–60. https://doi.org/10.1038/npp.2015.275

Article 
CAS 
PubMed 

Google Scholar 

Center for Drug Evaluation and Research (CDER) Approval Package for Application number: 21-977/S037. Vyvanse (lisdexamfetamine dimesylate) for the treatment of ‘Moderate to Severe Binge Eating Disorder (BED)’ 30 Jan, 2015. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/021977Orig1s037.pdf.

Koblan KS, Hopkins SC, Sarma K, Gallina N, Jin F, Levy-Cooperman N, et al. Assessment of human abuse potential of dasotraline compared to methylphenidate and placebo in recreational stimulant users. Drug Alcohol Depend. 2016;159:26–34. https://doi.org/10.1016/j.drugalcdep.2015.10.029

Article 
CAS 
PubMed 

Google Scholar 

Koblan KS, Hopkins SC, Sarma K, Jin F, Goldman R, Kollins SH, et al. Dasotraline for the treatment of attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled, proof-of-concept trial in adults. Neuropsychopharmacology. 2015;40:2745–52. https://doi.org/10.1038/npp.2015.124

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Hopkins SC, Sunkaraneni S, Skende E, Hing J, Passarell JA, Loebel A, et al. Pharmacokinetics and exposure-response relationships of dasotraline in the treatment of attention-deficit/hyperactivity disorder in adults. Clin Drug Investig. 2016;36:137–46. https://doi.org/10.1007/s40261-015-0358-7

Article 
CAS 
PubMed 

Google Scholar 

Findling RL, Adler LA, Spencer TJ, Goldman R, Hopkins SC, Koblan KS, et al. Dasotraline in children with attention-deficit/hyperactivity disorder: a six-week, placebo-controlled, fixed-dose trial. J Child Adolesc Psychopharmacol. 29:80–89. https://doi.org/10.1089/cap.2018.0083.

Navia B, Hudson JI, McElroy SL, et al. (2017) Dasotraline for the treatment of moderate to severe binge eating disorder in adults: results from a randomized,double-blind, placebo-controlled study. In: Proceedings of the 170th annual meeting of the American Psychiatric Association (APA), May 20–24, 2017; San Diego, CA, USA. Poster.

Citrome L, Goldman R, Mandel M, Tsai J, Deng L, Pikalov A, et al. (2019) Effect of dasotraline on body weight in patients with binge-eating disorder. In: Proceedings of the 172nd annual meeting of the American Psychiatric Association (APA); 2019; May 18–22, San Francisco, Poster P7-079.

Navia B, Hudson JL, McElroy SL, Guerdjikova A, Deng L, Sarma K, et al. (2018) Dasotraline for treatment of adults with binge-eating disorder: effect on behavioral outcomes. In: Proceedings of the 172nd annual meeting of the American Psychiatric Association (APA). May 5–9, 2018; New York USA. Poster.

McElroy SL, Hudson JI, Grilo CM, Guerdjikova AI, Deng L, Koblan KS, et al. Efficacy and safety of dasotraline in adults with binge-eating disorder: a randomized, placebo-controlled, flexible-dose clinical trial. J Clin Psychiatry. 2020;81:19m13068 https://doi.org/10.4088/JCP.19m13068

Article 
PubMed 

Google Scholar 

Grilo CM, McElroy SL, Hudson JI, Tsai J, Navia B, Goldman R, et al. Efficacy and safety of dasotraline in adults with binge-eating disorder: a randomized, placebo-controlled, fixed-dose clinical trial. CNS Spectr. 2020;19:1–10. https://doi.org/10.1017/S1092852920001406

Article 

Google Scholar 

Tsai J, Hudson JI, McElroy SL, et al. (2019) Efficacy and safety of dasotraline in adults with binge-eating disorder: a randomized, double-blind, fixed-dose trial. American Psychiatric Association, May 18–22, 2019, San Francisco, USA. Poster.

Rowley HL, Kulkarni R, Gosden J, Brammer R, Hackett D, Heal DJ. Lisdexamfetamine and immediate release d-amfetamine – differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity. Neuropharmacology. 2012;63:1064–74. https://doi.org/10.1016/j.neuropharm.2012.07.008

Article 
CAS 
PubMed 

Google Scholar 

Rowley HL, Kulkarni RS, Gosden J, Brammer RJ, Hackett D, Heal DJ. Differences in the neurochemical and behavioural profiles of lisdexamfetamine methylphenidate and modafinil revealed by simultaneous dual-probe microdialysis and locomotor activity measurements in freely-moving rats. J Psychopharmacol. 2014;28:254–69. https://doi.org/10.1177/0269881113513850

Article 
CAS 
PubMed 

Google Scholar 

Rowley HL, Kulkarni RS, Pinder L, et al. (2017) Dasotraline—evaluation of its dopamine reuptake characteristics in comparison to stimulants and non-stimulants by microdialysis in the nucleus accumbens of freely-moving rats. Society for Neurosciences Meeting, Washington, November 11–15, 2017. Abstract 557.23. Neuroscience Meeting Planner: https://www.abstractsonline.com/pp8/index.html#!/4376.

Heal DJ, Kulkarni RS, Pinder L, et al. Dasotraline is a monoamine reuptake inhibitor not a releasing agent as revealed by tetrodotoxin (TTX) sensitivity in microdialysis in the nucleus accumbens of freely-moving rats. Society for Neurosciences Meeting, Washington, November 11–15, 2017. 201A7. Abstract 557.21. Neuroscience Meeting Planner: https://www.abstractsonline.com/pp8/index.html#!/4376.

Rothman RB, Baumann MH, Dersch CM, Romero DV, Rice KC, et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse. 2001;39:32–41. doi: 10.1002/1098-2396(20010101)39:13.0.CO;2-3

Article 
CAS 
PubMed 

Google Scholar 

Devlin MJ, Goldfein JA, Carino JS, Wolk SL. Open treatment of overweight binge eaters with phentermine and fluoxetine as an adjunct to cognitive-behavioral therapy. Int J Eat Disord. 2000;28:325–32. doi: 10.1002/1098-108x(200011)28:33.0.co;2-3

Article 
CAS 
PubMed 

Google Scholar 

Alger SA, Malone M, Cerulli J, Fein S, Howard L. Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. Obes Res. 1999;7:469–76. https://doi.org/10.1002/j.1550-8528.1999.tb00435.x

Article 
CAS 
PubMed 

Google Scholar 

Safer DL, Adler S, Dalai SS, Bentley JP, Toyama H, Pajarito S, et al. A randomized, placebo-controlled crossover trial of phentermine-topiramate ER in patients with binge-eating disorder and bulimia nervosa. Int J Eat Disord. 2020;53:266–77. https://doi.org/10.1002/eat.23192

Article 
PubMed 

Google Scholar 

Guerdjikova AI, Williams S, Blom TJ, Mori N, McElroy SL.Combination phentermine-topiramate extended release for the treatment of binge eating disorder: an open-label, prospective study.Innov Clin Neurosci. 2018;15:17–21.

PubMed 
PubMed Central 

Google Scholar 

Buckett WR, Thomas PC, Luscombe GP. The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12:575–84. https://doi.org/10.1016/0278-5846(88)90003-6

Article 
CAS 
PubMed 

Google Scholar 

Luscombe GP, Slater NA, Lyons MB, Wynne RD, Scheinbaum ML, Buckett WR. Effect on radiolabelled-monoamine uptake in vitro of plasma taken from healthy volunteers administered the antidepressant sibutramine HCl. Psychopharmacology. 1990;100:345–9. https://doi.org/10.1007/BF02244604

Article 
CAS 
PubMed 

Google Scholar 

Heal DJ, Cheetham SC. The pharmacology of sibutramine, the first serotonin and noradrenaline reuptake inhibitor to be developed for the treatment of obesity. La Lettre du Pharmacologue. 1997;11(Suppl 10):S3–S8.

Google Scholar 

Rowley HL, Butler SA, Prow MR, Dykes SG, Aspley S, Kilpatrick IC, et al. Comparison of the effects of sibutramine and other weight-modifying drugs on extracellular dopamine in the nucleus accumbens of freely moving rats. Synapse. 2000;38:167–76. 10.1002/1098-2396(200011)38:23.0.CO;2-W

Article 
CAS 
PubMed 

Google Scholar 

Heal DJ, Frankland AT, Gosden J, Hutchins LJ, Prow MR, Luscombe GP, et al. A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine. Psychopharmacology. 1992;107:303–9. https://doi.org/10.1007/BF02245152

Article 
CAS 
PubMed 

Google Scholar 

Appolinario JC, Bacaltchuk J, Sichieri R, Claudino AM, Godoy-Matos A, Morgan C, et al. A randomized, double-blind, placebo-controlled study of sibutramine in the treatment of binge-eating disorder. Arch Gen Psychiatry. 2003;60:1109–16. https://doi.org/10.1001/archpsyc.60.11.1109

Article 
CAS 
PubMed 

Google Scholar 

Mitchell JE, Gosnell BA, Roerig JL, de Zwaan M, Wonderlich SA, Crosby RD, et al. Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm. Obes Res. 2003;11:599–602. https://doi.org/10.1038/oby.2003.85

Article 
CAS 
PubMed 

Google Scholar 

Milano W, Petrella C, Casella A, Capasso A, Carrino S, Milano L. Use of sibutramine, an inhibitor of the reuptake of serotonin and noradrenaline, in the treatment of binge eating disorder: a placebo-controlled study. Adv Ther. 2005;22:25–31. https://doi.org/10.1007/BF02850181

Article 
CAS 
PubMed 

Google Scholar 

Wilfley DE, Crow SJ, Hudson JI, Mitchell JE, Berkowitz RI, Blakesley V, et al. Efficacy of sibutramine for the treatment of binge eating disorder: a randomized multicenter placebo-controlled double-blind study. Am J Psychiatry. 2008;165:51–8. https://doi.org/10.1176/appi.ajp.2007.06121970

Article 
PubMed 

Google Scholar 

APA (American Psychiatric Association): Diagnostic and statistical manual of mental disorders, Fourth Edition. Arlington, VA. American Psychiatric Association 1994.

Guerdjikova AI, McElroy SL, Winstanley EL, Nelson EB, Mori N, McCoy J, et al. Duloxetine in the treatment of binge eating disorder with depressive disorders: a placebo-controlled trial. Int J Eat Disord. 2012;45:281–9. https://doi.org/10.1002/eat.20946

Article 
PubMed 

Google Scholar 

Wong DT, Bymaster FP, Mayle DA, Reid LR, Krushinski JH, Robertson DW. LY248686, a new inhibitor of serotonin and norepinephrine uptake. Neuropsychopharmacology. 1993;8:23–33. https://doi.org/10.1038/npp.1993.4

Article 
CAS 
PubMed 

Google Scholar 

Heal DJ, Cheetham SC, Smith SL. The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety. Neuropharmacology. 2009;57:608–18. https://doi.org/10.1016/j.neuropharm.2009.08.020

Article 
CAS 
PubMed 

Google Scholar 

Biederman J, Swanson JM, Wigal SB, Kratochvil CJ, Boellner SW, Earl CQ, et al. Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, flexible-dose study. Pediatrics. 2005;116:e777–84. https://doi.org/10.1542/peds.2005-0617

Article 
PubMed 

Google Scholar 

Wigal SB, Biederman J, Swanson JM, Yang R, Greenhill LL. Efficacy and safety of modafinil film-coated tablets in children and adolescents with or without prior stimulant treatment for attention-deficit/hyperactivity disorder: pooled analysis of 3 randomized, double-blind, placebo-controlled studies. Prim Care Companion J Clin Psychiatry. 2006;8:352–60.

PubMed 
PubMed Central 

Google Scholar 

McElroy SL, Guerdjikova AI, Mori N, Blom TJ, Williams S, Casuto LS, et al. Armodafinil in binge eating disorder: a randomized, placebo-controlled trial. Int Clin Psychopharmacol. 2015;30:209–15. https://doi.org/10.1097/YIC.0000000000000079

Article 
PubMed 

Google Scholar 

Hyttel J. Citalopram-pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6:277–95. https://doi.org/10.1016/s0278-5846(82)80179-6

Article 
CAS 
PubMed 

Google Scholar 

Richelson E, Pfenning M. Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. Eur J Pharmacol. 1984;104:277–86. https://doi.org/10.1016/0014-2999(84)90403-5

Article 
CAS 
PubMed 

Google Scholar 

Ascher JA, Cole JO, Colin JN, Feighner JP, Ferris RM, Fibiger HC, et al. Bupropion: a review of its mechanism of antidepressant activity. J Clin Psychiatry. 1995;56:395–401.

CAS 
PubMed 

Google Scholar 

White MA, Grilo CM. Bupropion for overweight women with binge-eating disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2013;74:400–6. https://doi.org/10.4088/JCP.12m08071

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Calandra C, Russo RG, Luca M. Bupropion versus sertraline in the treatment of depressive patients with binge eating disorder: retrospective cohort study. Psychiatr Q. 2012;83:177–85. https://doi.org/10.1007/s11126-011-9192-0

Article 
PubMed 

Google Scholar 

Carbone EA, Caroleo M, Rania M, Calabrò G, Staltari FA, de Filippis R, et al. An open-label trial on the efficacy and tolerability of naltrexone/bupropion SR for treating altered eating behaviours and weight loss in binge eating disorder. Eat Weight Disord. 2021;26:779–88. https://doi.org/10.1007/s40519-020-00910-x

Article 
PubMed 

Google Scholar 

Guerdjikova AI, Walsh B, Shan K, Halseth AE, Dunayevich E, McElroy SL. Concurrent improvement in both binge eating and depressive symptoms with naltrexone/bupropion therapy in overweight or obese subjects with major depressive disorder in an open-label, uncontrolled study. Adv Ther. 2017;34:2307–15. https://doi.org/10.1007/s12325-017-0613-9

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Bolden-Watson C, Richelson E. Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sci. 1993;52:1023–9. https://doi.org/10.1016/0024-3205(93)90194-8

Article 
CAS 
PubMed 

Google Scholar 

Halford JC, Harrold JA, Boyland EJ, Lawton CL, Blundell JE. Serotonergic drugs: effects on appetite expression and use for the treatment of obesity. Drugs. 2007;67:27–55. https://doi.org/10.2165/00003495-200767010-00004

Article 
CAS 
PubMed 

Google Scholar 

Grignaschi G, Neill JC, Petrini A, Garattini S, Samanin R. Feeding pattern studies suggest that d-fenfluramine and sertraline specifically enhance the state of satiety in rats. Eur J Pharmacol. 1992;211:137–42. https://doi.org/10.1016/0014-2999(92)90520-e

Article 
CAS 
PubMed 

Google Scholar 

Greeno CG, Wing RR. A double-blind, placebo-controlled trial of the effect of fluoxetine on dietary intake in overweight women with and without binge-eating disorder. Am J Clin Nutr. 1996;64:267–73. https://doi.org/10.1093/ajcn/64.3.267

Article 
CAS 
PubMed 

Google Scholar 

Ward AS, Comer SD, Haney M, Fischman MW, Foltin RW. Fluoxetine-maintained obese humans: effect on food intake and body weight. Physiol Behav. 1999;66:815–21. https://doi.org/10.1016/s0031-9384(99)00020-7

Article 
CAS 
PubMed 

Google Scholar 

Levine LR, Enas GG, Thompson WL, Byyny RL, Dauer AD, Kirby RW, et al. Use of fluoxetine, a selective serotonin-uptake inhibitor, in the treatment of obesity: a dose-response study (with a commentary by Michael Weintraub). Int J Obes. 1989;13:635–45.

CAS 
PubMed 

Google Scholar 

Abell CA, Farquhar DL, Galloway SM, Steven F, Philip AE, Munro JF. Placebo controlled double-blind trial of fluvoxamine maleate in the obese. J Psychosom Res. 1986;30:143–6. https://doi.org/10.1016/0022-3999(86)90043-7

Article 
CAS 
PubMed 

Google Scholar 

Goldstein DJ, Rampey AH Jr, Roback PJ, Wilson MG, Hamilton SH, Sayler ME, et al. Efficacy and safety of long-term fluoxetine treatment of obesity-maximizing success. Obes Res. 1995;3(Suppl 4):481S–490S. https://doi.org/10.1002/j.1550-8528.1995.tb00216.x

Article 
CAS 
PubMed 

Google Scholar 

Weiss M, Hechtman L. A randomized double-blind trial of paroxetine and/or dextroamphetamine and problem-focused therapy for attention-deficit/hyperactivity disorder in adults. J Clin Psychiatry. 2006;67:611–9. Adult ADHD Research Group

Article 
CAS 
PubMed 

Google Scholar 

Arnold LM, McElroy SL, Hudson JI, Welge JA, Bennett AJ, Keck PE. A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder. J Clin Psychiatry. 2002;63:1028–33. https://doi.org/10.4088/jcp.v63n1113

Article 
CAS 
PubMed 

Google Scholar 

Hudson JI, McElroy SL, Raymond NC, Crow S, Keck PE Jr, Carter WP, et al. Fluvoxamine in the treatment of binge-eating disorder: a multicenter placebo-controlled, double-blind trial. Am J Psychiatry. 1998;155:1756–62. https://doi.org/10.1176/ajp.155.12.1756

Article 
CAS 
PubMed 

Google Scholar 

McElroy SL, Casuto LS, Nelson EB, Lake KA, Soutullo CA, Keck PE Jr, et al. Placebo-controlled trial of sertraline in the treatment of binge eating disorder. Am J Psychiatry. 2000;157:1004–6. https://doi.org/10.1176/appi.ajp.157.6.1004

Article 
CAS 
PubMed 

Google Scholar 

McElroy SL, Hudson JI, Malhotra S, Welge JA, Nelson EB, Keck PE Jr. Citalopram in the treatment of binge-eating disorder: a placebo-controlled trial. J Clin Psychiatry. 2003;64:807–13. https://doi.org/10.4088/jcp.v64n0711

Article 
CAS 
PubMed 

Google Scholar 

Devlin MJ, Goldfein JA, Petkova E, Jiang H, Raizman PS, Wolk S, et al. Cognitive behavioral therapy and fluoxetine as adjuncts to group behavioral therapy for binge eating disorder. Obes Res. 2005;13:1077–88. https://doi.org/10.1038/oby.2005.126

Article 
PubMed 

Google Scholar 

Grilo CM, Masheb RM, Wilson GT. Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: a randomized double-blind placebo-controlled comparison. Biol Psychiatry. 2005;57:301–9. https://doi.org/10.1016/j.biopsych.2004.11.002

Article 
CAS 
PubMed 

Google Scholar 

Pearlstein T, Spurell E, Hohlstein LA, Gurney V, Read J, Fuchs C, et al. A double-blind, placebo-controlled trial of fluvoxamine in binge eating disorder: a high placebo response. Arch Womens Ment Health. 2003;6:147–51. https://doi.org/10.1007/s00737-003-0172-8

Article 
CAS 
PubMed 

Google Scholar 

Guerdjikova AI, McElroy SL, Kotwal R, Welge JA, Nelson E, Lake K, et al. High-dose escitalopram in the treatment of binge-eating disorder with obesity: a placebo-controlled monotherapy trial. Hum Psychopharmacol. 2008;23:1–11. https://doi.org/10.1002/hup.899

Article 
CAS 
PubMed 

Google Scholar 

Leombruni P, Pierò A, Lavagnino L, Brustolin A, Campisi S, Fassino S. A randomized, double-blind trial comparing sertraline and fluoxetine 6-month treatment in obese patients with Binge Eating Disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1599–605. https://doi.org/10.1016/j.pnpbp.2008.06.005

Article 
CAS 
PubMed 

Google Scholar 

Sanchez C, Asin KE, Artigas F. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther. 2015;145:43–57. https://doi.org/10.1016/j.pharmthera.2014.07.001.

Article 
CAS 
PubMed 

Google Scholar 

Grant JE, Valle S, Cavic E, Redden SA, Chamberlain SR. A double-blind, placebo-controlled study of vortioxetine in the treatment of binge-eating disorder. Int J Eat Disord. 2019;52:786–94. https://doi.org/10.1002/eat.23078

Article 
PubMed 
PubMed Central 

Google Scholar 

Wong DT, Threlkeld PG, Best KL, Bymaster FP. A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain. J Pharmacol Exp Ther. 1982;222:61–5.

CAS 
PubMed 

Google Scholar 

McElroy SL, Guerdjikova A, Kotwal R, Welge JA, Nelson EB, Lake KA, et al. Atomoxetine in the treatment of binge-eating disorder: a randomized placebo-controlled trial. J Clin Psychiatry. 2007;68:390–8. https://doi.org/10.4088/jcp.v68n0306

Article 
CAS 
PubMed 

Google Scholar 

Dunn DW, Austin JK, Harezlak J, Ambrosius WT. ADHD and epilepsy in childhood. Dev Med Child Neurol. 2003;45:50–4.

Article 
PubMed 

Google Scholar 

Pellock JM. Understanding co-morbidities affecting children with epilepsy. Neurology. 2004;62(5 Suppl 2):S17–23. https://doi.org/10.1212/wnl.62.5_suppl_2.s17

Article 
CAS 
PubMed 

Google Scholar 

Schubert R. Attention deficit disorder and epilepsy. Pediatr Neurol. 2005;32:1–10. https://doi.org/10.1016/j.pediatrneurol.2004.06.007

Article 
PubMed 

Google Scholar 

Dunn DW, Kronenberger WG. Childhood epilepsy, attention problems, and ADHD: review and practical considerations. Semin Pediatr Neurol. 2005;12:222–8. https://doi.org/10.1016/j.spen.2005.12.004

Article 
PubMed 

Google Scholar 

Hamoda HM, Guild DJ, Gumlak S, Travers BH, Gonzalez-Heydrich J. Association between attention-deficit/hyperactivity disorder and epilepsy in pediatric populations. Expert Rev Neurother. 2009;9:1747–54. https://doi.org/10.1586/ern.09.128

Article 
PubMed 

Google Scholar 

Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004;5:553–64. https://doi.org/10.1038/nrn1430

Article 
CAS 
PubMed 

Google Scholar 

Öncü B, Er O, Çolak B, Nutt DJ. Lamotrigine for attention deficit-hyperactivity disorder comorbid with mood disorders: a case series. J Psychopharmacol. 2014;28:282–3. https://doi.org/10.1177/0269881113493365

Article 
CAS 
PubMed 

Google Scholar 

Han SA, Yang EJ, Song MK, Kim SJ. Effects of lamotrigine on attention-deficit hyperactivity disorder in pediatric epilepsy patients. Korean J Pediatr. 2017;60:189–95. https://doi.org/10.3345/kjp.2017.60.6.189

Article 
PubMed 
PubMed Central 

Google Scholar 

Guerdjikova AI, McElroy SL, Welge JA, Nelson E, Keck PE, Hudson JI. Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial. Int Clin Psychopharmacol. 2009;24:150–8. https://doi.org/10.1097/YIC.0b013e328329c7b5

Article 
PubMed 

Google Scholar 

Langtry HD, Gillis JC, Topiramate Davis R. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of epilepsy. Drugs.1997;54:752–73. https://doi.org/10.2165/00003495-199754050-00009.

Article 
CAS 
PubMed 

Google Scholar 

White HS. Comparative anticonvulsant and mechanistic profile of the established and newer antiepileptic drugs. Epilepsia. 1999;40(Suppl 5):S2–S10. https://doi.org/10.1111/j.1528-1157.1999.tb00913.x

Article 
CAS 
PubMed 

Google Scholar 

Shank RP, Gardocki JF, Streeter AJ, Maryanoff BE. An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia. 2000;41(S1):3–9.

Article 
CAS 
PubMed 

Google Scholar 

McElroy SL, Arnold LM, Shapira NA, Keck PE Jr, Rosenthal NR, Karim MR, et al. Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial. Am J Psychiatry. 2003;160:255–61. https://doi.org/10.1176/appi.ajp.160.2.255

Article 
PubMed 

Google Scholar 

McElroy SL, Hudson JI, Capece JA, Beyers K, Fisher AC, Rosenthal NR. Topiramate for the treatment of binge eating disorder associated with obesity: a placebo-controlled study. Biol Psychiatry. 2007;61:1039–48. https://doi.org/10.1016/j.biopsych.2006.08.008

Article 
CAS 
PubMed 

Google Scholar 

Masuda Y, Ishizaki M, Shimizu M. Zonisamide: pharmacology and clinical efficacy in epilepsy. CNS Drug Rev. 1998;4:341–60. https://doi.org/10.1111/j.1527-3458.1998.tb00075.x

Article 
CAS 
PubMed 

Google Scholar 

Leppik IE. Zonisamide. Epilepsia. 1999;40(Suppl 5):S23–9. https://doi.org/10.1111/j.1528-1157.1999.tb00916.x

Article 
CAS 
PubMed 

Google Scholar 

De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005;15:2315–20. https://doi.org/10.1016/j.bmcl.2005.03.032

Article 
CAS 
PubMed 

Google Scholar 

Shank RP, Smith-Swintosky VL, Maryanoff BE. Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate. J Enzyme Inhib Med Chem. 2008;23:271–6. https://doi.org/10.1080/14756360701507001.

Article 
CAS 
PubMed 

Google Scholar 

Wallingford NM, Sinnayah P, Bymaster FP, Gadde KM, Krishnan RK, McKinney AA, et al. Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats. Neuropsychopharmacology. 2008;33:2922–33. https://doi.org/10.1038/npp.2008.9

Article 
CAS 
PubMed 

Google Scholar 

Ghanizadeh A, Nikseresht MS, Sahraian A. The effect of zonisamide on antipsychotic-associated weight gain in patients with schizophrenia: a randomized, double-blind, placebo-controlled clinical trial. Schizophr Res. 2013;147:110–5. https://doi.org/10.1016/j.schres.2013.03.021

Article 
PubMed 

Google Scholar 

Nguyen ML, Pirzada MH, Shapiro MA. Zonisamide for weight loss in adolescents. J Pediatr Pharmacol Ther. 2013;18:311–4. https://doi.org/10.5863/1551-6776-18.4.311

Article 
PubMed 
PubMed Central 

Google Scholar 

Gadde KM, Kopping MF, Wagner HR 2nd, Yonish GM, Allison DB, Bray GA. Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial. Arch Intern Med. 2012;172:1557–64. https://doi.org/10.1001/2013.jamainternmed.99

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

McElroy SL, Kotwal R, Guerdjikova AI, Welge JA, Nelson EB, Lake KA, et al. Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial. J Clin Psychiatry. 2006;67:1897–906. https://doi.org/10.4088/jcp.v67n1209

Article 
CAS 
PubMed 

Google Scholar 

Zornoza T, Cano MJ, Polache A, Granero L. Pharmacology of acamprosate: an overview. CNS Drug Rev. 2003;9:359–74. https://doi.org/10.1111/j.1527-3458.2003.tb00260.x

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Mann K, Kiefer F, Spanagel R, Littleton J. Acamprosate: recent findings and future research directions. Alcohol Clin Exp Res. 2008;32:1105–10. https://doi.org/10.1111/j.1530-0277.2008.00690.x

Article 
CAS 
PubMed 

Google Scholar 

Mason BJ, Heyser CJ. Acamprosate: a prototypic neuromodulator in the treatment of alcohol dependence. CNS Neurol Disord Drug Targets. 2010;9:23–32. https://doi.org/10.2174/187152710790966641

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

McElroy SL, Guerdjikova AI, Winstanley EL, O’Melia AM, Mori N, McCoy J, et al. Acamprosate in the treatment of binge eating disorder: a placebo-controlled trial. Int J Eat Disord. 2011;44:81–90. https://doi.org/10.1002/eat.20876

Article 
PubMed 

Google Scholar 

Wentland MP, Lou R, Lu Q, Bu Y, Denhardt C, Jin J, et al. Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009;19:2289–94. https://doi.org/10.1016/j.bmcl.2009.02.078

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Atkinson RL, Berke LK, Drake CR, Bibbs ML, Williams FL, Kaiser DL. Effects of long-term therapy with naltrexone on body weight in obesity. Clin Pharmacol Ther. 1985;38:419–22. https://doi.org/10.1038/clpt.1985.197

Article 
CAS 
PubMed 

Google Scholar 

Mitchell JE, Morley JE, Levine AS, Hatsukami D, Gannon M, Pfohl D. High-dose naltrexone therapy and dietary counseling for obesity. Biol Psychiatry. 1987;22:35–42. https://doi.org/10.1016/0006-3223(87)90127-2

Article 
CAS 
PubMed 

Google Scholar 

McElroy SL, Guerdjikova AI, Blom TJ, Crow SJ, Memisoglu A, Silverman BL, et al. A placebo-controlled pilot study of the novel opioid receptor antagonist ALKS-33 in binge eating disorder. Int J Eat Disord. 2013;46:239–45. https://doi.org/10.1002/eat.22114

Article 
PubMed 

Google Scholar 

Ignar DM, Goetz AS, Noble KN, Carballo LH, Stroup AE, Fisher JC, et al. Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist. J Pharmacol Exp Ther. 2011;339:24–34. https://doi.org/10.1124/jpet.111.180943

Article 
CAS 
PubMed 

Google Scholar 

Ziauddeen H, Chamberlain SR, Nathan PJ, Koch A, Maltby K, Bush M, et al. Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects. Mol Psychiatry. 2013;18:1287–93. https://doi.org/10.1038/mp.2012.154

Article 
CAS 
PubMed 

Google Scholar 

Misgeld U, Bijak M, Jarolimek W. A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. Prog Neurobiol. 1995;46:423–62. https://doi.org/10.1016/0301-0082(95)00012-k

Article 
CAS 
PubMed 

Google Scholar 

Costantino G, Macchiarulo A, Entrena Guadix A, Pellicciari R. QSAR and molecular modeling studies of baclofen analogues as GABA(B) agonists. insights into the role of the aromatic moiety in GABA(B) binding and activation. J Med Chem. 2001;44:1827–32. https://doi.org/10.1021/jm0100133

Article 
CAS 
PubMed 

Google Scholar 

Corwin RL, Boan J, Peters KF, Ulbrecht JS. Baclofen reduces binge eating in a double-blind, placebo-controlled, crossover study. Behav Pharmacol. 2012;23:616–25. https://doi.org/10.1097/FBP.0b013e328357bd62

Article 
CAS 
PubMed 

Google Scholar 

Pataky Z, Gasteyger C, Ziegler O, Rissanen A, Hanotin C, Golay A. Efficacy of rimonabant in obese patients with binge eating disorder. Exp Clin Endocrinol Diabetes. 2013;121:20–6. https://doi.org/10.1055/s-0032-1329957

Article 
CAS 
PubMed 

Google Scholar 

Guerciolini R. Mode of action of orlistat. Int J Obes Relat Metab Disord. 1997;21(Suppl 3):S12–23.

CAS 
PubMed 

Google Scholar 

Golay A, Laurent-Jaccard A, Habicht F, Gachoud JP, Chabloz M, Kammer A, et al. Effect of orlistat in obese patients with binge eating disorder. Obes Res. 2005;13:1701–8. https://doi.org/10.1038/oby.2005.208

Article 
CAS 
PubMed 

Google Scholar 

Grilo CM, Masheb RM. Rapid response predicts binge eating and weight loss in binge eating disorder: findings from a controlled trial of orlistat with guided self-help cognitive behavioral therapy. Behav Res Ther. 2007;45:2537–50. https://doi.org/10.1016/j.brat.2007.05.010.

Article 
PubMed 
PubMed Central 

Google Scholar 

Grilo CM, White MA. Orlistat with behavioral weight loss for obesity with versus without binge eating disorder: randomized placebo-controlled trial at a community mental health center serving educationally and economically disadvantaged Latino/as. Behav Res Ther. 2013;51:167–75. https://doi.org/10.1016/j.brat.2013.01.002

Article 
PubMed 
PubMed Central 

Google Scholar 

Allison KC, Wadden TA, Sarwer DB, Fabricatore AN, Crerand CE, Gibbons LM, et al. Night eating syndrome and binge eating disorder among persons seeking bariatric surgery: prevalence and related features. Surg Obes Relat Dis. 2006;2:153–8. https://doi.org/10.1016/j.soard.2006.03.014

Article 
PubMed 

Google Scholar 

Dawes AJ, Maggard-Gibbons M, Maher AR, Booth MJ, Miake-Lye I, Beroes JM, et al. Mental health conditions among patients seeking and undergoing bariatric surgery: a meta-analysis. JAMA. 2016;315:150–63. https://doi.org/10.1001/jama.2015.18118

Article 
CAS 
PubMed 

Google Scholar 

Heal DJ, Smith SL. Prospects for new drugs to treat binge-eating disorder: insights from psychopathology and neuropharmacology. J Psychopharmacol. 2021;28:2698811211032475 https://doi.org/10.1177/02698811211032475

Article 

Google Scholar 



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