Chesney E, Goodwin GM, Fazel S. Risks of all-cause and suicide mortality in mental disorders: a meta-review. World Psychiatry. 2014;13:156–60.
Anversa RG, Muthmainah M, Sketriene D, Gogos A, Sumithran P, Brown RM. A review of sex differences in the mechanisms and drivers of overeating. Front Neuroendocrinol. 2021;63:100941.
Google Scholar
François M, Fernández-Gayol O, Zeltser LM. A Framework for Developing Translationally Relevant Animal Models of Stress-Induced Changes in Eating Behavior. Biol Psychiatry. 2022;91:888–97.
Google Scholar
Substance Abuse and Mental Health Services Administration. National Survey on Drug Use and Health. 2018. https://www.samhsa.gov/data/release/2018-national-survey-drug-use-and-health-nsduh-releases. Accessed on 13 Jan 2023.
Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen HU. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res. 2012;21:169–84.
Google Scholar
Wong L, Stammers L, Churilov L, Price S, Ekinci E, Sumithran P. Emotional eating in patients attending a specialist obesity treatment service. Appetite. 2020;151:104708.
Google Scholar
Klump KL, Racine S, Hildebrandt B, Sisk CL. Sex differences in binge eating patterns in male and female adult rats. Int J Eat Disord. 2013;46:729–36.
Google Scholar
Culbert KM, Sisk CL, Klump KL. A Narrative Review of Sex Differences in Eating Disorders: Is There a Biological Basis? Clin Ther. 2021;43:95–111.
Google Scholar
Anversa RG, Campbell EJ, Ch’ng SS, Gogos A, Lawrence AJ, Brown RM. A model of emotional stress-induced binge eating in female mice with no history of food restriction. Genes Brain Behav. 2020;19:e12613.
Google Scholar
Corwin RL, Avena NM, Boggiano MM. Feeding and reward: perspectives from three rat models of binge eating. Physiol Behav. 2011;104:87–97.
Google Scholar
Campbell EJ, Lawrence AJ. It’s more than just interoception: The insular cortex involvement in alcohol use disorder. J Neurochem. 2021;157:1644–51.
Google Scholar
Gogolla N. The insular cortex. Curr Biol. 2017;27:R580–86.
Google Scholar
Craig AD. How do you feel- now? The anterior insula and human awareness. Nat Rev Neurosci. 2009;10:59–70.
Google Scholar
Campbell EJ, Flanagan JPM, Walker LC, Hill M, Marchant NJ, Lawrence AJ. Anterior Insular Cortex is Critical for the Propensity to Relapse Following Punishment-Imposed Abstinence of Alcohol Seeking. J Neurosci. 2019;39:1077–87.
Google Scholar
Killgore WD, Yurgelun-Todd DA. Affect modulates appetite-related brain activity to images of food. Int J Eat Disord. 2006;39:357–63.
Google Scholar
Killgore WD, Yurgelun-Todd DA. Sex differences in cerebral responses to images of high versus low-calorie food. Neuroreport. 2010;21:354–58.
Google Scholar
Sharmuller W, Ubel S, Ebner F, Schienle A. Appetite regulation during food cue exposure: a comparison of normal-weight and obese women. Neurosci Lett. 2012;518:106–10.
Rothemund Y, Preuschhof C, Bohner G, Bauknecht HC, Klingebiel R, Flor H, et al. Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. Neuroimage. 2007;37:410–21.
Google Scholar
Stoeckel LE, Weller RE, Cook EW 3rd, Twieg DB, Knowlton RC, Cox JE. Widespread reward-system activation in obese women in response to pictures of high-calorie foods. Neuroimage. 2008;41:636–47.
Google Scholar
Boutelle KN, Wierenga CE, Bischoff-Grethe A, Melrose AJ, Grenesko-Stevens E, Paulus MP, et al. Increased brain response to appetitive tastes in the insula and amygdala in obese compared with healthy weight children when sated. Int J Obes. 2015;39:620–28.
Google Scholar
Wonderlich JA, Breithaupt LE, Crosby RD, Thompson JC, Engel SG, Fischer S. The relation between craving and binge eating: Integrating neuroimaging and ecological momentary assessment. Appetite. 2017;117:294–302.
Google Scholar
Kirson D, Spierling Bagsic SR, Murphy J, Chang H, Vlkolinsky R, Pucci SN, et al. Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand. Neuropharmacology. 2022;208:108980.
Google Scholar
Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, et al. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology. 2020;45:579–88.
Google Scholar
Gehrlach DA, Weiand C, Gaitanos TN, Cho E, Klein AS, Hennrich A, et al. A whole-brain connectivity map of mouse insular cortex. Elife. 2020;9:e55585.
Google Scholar
Borgius L, Restrepo CE, Leao RN, Saleh N, Kiehn O. A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons. Mol Cell Neurosci. 2010;45:245–57.
Google Scholar
Paxinos G, Franklin KBJ. The mouse brain in stereotaxic coordinates, 3rd ed. Academic Press: Sydney, NSW; 2008.
Mahler SV, Vazey EM, Beckley JT, Keistler CR, McGlinchey EM, Kaufling J, et al. Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci. 2014;17:577–85.
Google Scholar
Rowson SA, Pleil KE. Influences of Stress and Sex on the Paraventricular Thalamus: Implications for Motivated Behavior. Front Behav Neurosci. 2021;15:636203.
Google Scholar
Micioni Di Bonaventura MV, Vitale G, Massi M, Cifani C. Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats. J Obes. 2012;2012:956137.
Google Scholar
Kim J, Lee S, Fang YY, Shin A, Park S, et al. Rapid, biphasic CRF neuronal responses encode positive and negative valence. Nat Neurosci. 2019;22:576–85.
Google Scholar
Di Polito N, Stylianakis AA, Richardson R, Baker KD. Real-World Intake of Dietary Sugars Is Associated with Reduced Cortisol Reactivity Following an Acute Physiological Stressor. Nutrients. 2023;15:209.
Google Scholar
Epel E, Lapidus R, McEwen B, Brownell K. Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinol. 2011;26:37–49.
Sinha R, Jastreboff AM. Stress as a common risk factor for obesity and addiction. Biol Psychiatry. 2013;73:827–35.
Google Scholar
Okamura H, Yasugaki S, Suzuki-Abe H, Arai Y, Sakurai K, Yanagisawa M, et al. Long-term effects of repeated social defeat stress on brain activity during social interaction in BALB/c mice. ENeuro. 2022;9:ENEURO.0068–22.2022.
Google Scholar
Kimborough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, et al. Brain-wide functional architecture remodelling by alcohol dependence and abstinence. Proc Natl Sci USA. 2020;117:2149–159.
Jimenez VA, Herman MA, Cuzon Carlson VC, Walter NA, Grant KA, Roberto M. Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys. Neuropsychopharmacol. 2019;44:982–93.
Google Scholar
Chrousos G. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5:374–81.
Google Scholar
Wang L, Kong QM, Li K, Li XN, Zeng YW, Chen C, et al. Altered intrinsic functional brain architecture in female patients with bulimia nervosa. J Psychiatry Neurosci. 2017;42:414–23.
Google Scholar
Do Monte F, Engelke D, Zhang X, Olivo L, O’Malley J, Fernandez-Leon J, et al. Thalamic Circuits Balancing Fear and Reward-Seeking Responses. Biol Psychiatry. 2020;89:S7–8.
Millan EZ, Ong Z, McNally GP. Paraventricular thalamus: Gateway to feeding, appetitive motivation, and drug addiction. Prog Brain Res. 2017;235:113–37.
Google Scholar
Kirouac GJ. Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior. Neurosci Biobehav Rev. 2015;56:315–29.
Google Scholar
Beas BS, Wright BJ, Skirzewski M, Leng Y, Hyun JH, et al. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nature Neurosci. 2018;21:963–73.
Google Scholar
Timofeeva E, Picard F, Duclos M, Deshaies Y, Richard D. Neuronal activation and corticotropin-releasing hormone expression in the brain of obese (fa/fa) and lean (fa/?) Zucker rats in response to refeeding. Eur J Neurosci. 2002;15:1013–29.
Google Scholar
Matzeu A, Cauvi G, Kerr TM, Weiss F, Martin-Fardon R. The paraventricular nucleus of the thalamus is differentially recruited by stimuli conditioned to the availability of cocaine versus palatable food. Addict Biol. 2017;22:70–77.
Google Scholar
Flagel SB, Cameron CM, Pickup KN, Watson SJ, Akil H, Robinson TE. A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions. Neuroscience. 2011;196:80–96.
Google Scholar
Dayas CV, McGranahan TM, Martin-Fardon R, Weiss F. Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse. Biol Psychiatry. 2007;63:152–57.
Google Scholar
Igelstrom KM, Herbison AE, Hyland BI. Enhanced c-Fos expression in superior colliculus, paraventricular thalamus and septum during learning of cue-reward association. Neuroscience. 2010;168:706–14.
Google Scholar
James MH, Charnley JL, Flynn JR, Smith DW, Dayas CV. Propensity to ‘relapse’ following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei. Neuroscience. 2011;199:235–42.
Google Scholar
Bubser M, Deutch AY. Stress induced Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites. Synapse. 1999;32:13–22.
Google Scholar
Lkhagvasuren B, Oka T, Nakamura Y, Hayashi H, Sudo N, Nakamura K. Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment. Neuroscience. 2014;272:34–57.
Google Scholar
Otake K, Kin K, Nakamura Y. Fos expression in afferents to the rat midline thalamus following immobilization stress. Neurosci Res. 2002;43:269–82.
Google Scholar
Bhatnagar S, Dallman M. Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress. Neuroscience. 1998;84:1025–39.
Google Scholar
Epel E, Lapidus R, McEwen B, Brownell K. Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinol. 2001;26:37–49.
Google Scholar
Adam TC, Epel ES. Stress, eating and the reward system. Physiol Behav. 2007;91:449–58.
Google Scholar
McGinty JF, Otis JM. HEterogeneity in the paraventricular thalamus: the traffic light of motivated behaviors. Front Behav Neurosci. 2020;14:590528.
Google Scholar
Matzeu A, Martin-Fardon R. Blockade of orexin receptors in the posterior paraventricular nucleus of the thalamus prevents stress-induced reinstatement of reward-seeking behavior in rats with a history of ethanol dependence. Front Integr Neurosci. 2020;14:599710.
Google Scholar
Otis JM, Zhu M, Namboodiri VMK, Cook CA, Medina-Colón EM, Quirk GJ. Paraventricular thalamus projection neurons integrate cortical and hypothalamic signals for cue-reward processing. Neuron. 2019;3:423–31.
Labouèbe G, Boutrel B, Tarussio D, Thorens B. Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior. Nat Neurosci. 2016;19:999–1002.
Google Scholar
Do-Monte FH, Minier-Toribio A, Quiñones-Laracuente K, Medina-Colón EM, Quirk GJ. Thalamic regulation of sucrose seeking during unexpected reward omission. Neuron. 2017;94:388–400.
Google Scholar
Christoffel DJ, Walsh JJ, Heifets BD, Hoerbelt P, Neuner S, Sun G, et al. Input-specific modulation of murine nucleus accumbens differentially regulates hedonic feeding. Nat Commun. 2021;12:2135.
Google Scholar
Zhu Y, Wienecke C, Nachtrab G, Chen X. A thalamic input to the nucleus accumbens mediates opiate dependence. Nature. 2016;530:219–22.
Google Scholar
Parsons W, Greiner E, Buczek L, Migliaccio J, Corbett E, Madden AMK, et al. Sex differences in activation of extra-hypothalamic forebrain areas during hedonic eating. Brain Struct Funct. 2022;227:2857–78.
Google Scholar
Corbett BF, Urban K, Luz S, Yan J, Arner J, Bhatnagar S. Sex differences in electrophysiological properties and voltage-gated ion channel expression in the paraventricular thalamic nucleus following repeated stress. Biol Sex Differ. 2022;13:51.
Google Scholar
Mather M, Lighthall NR, Nga L, Gorlick MA. Sex differences in how stress affects brain activity during face viewing. Neuroreport. 2010;21:933–37.
Google Scholar